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MELISSA SPORN, PH.D.
PH.D.
Clinical Psychologist
NPI: 1154467959Individual
Specialties, Licenses & Credentials
Clinical PsychologistPrimary
Psychologist — Clinical
Code: 103TC0700X
0810003407(VA)
Research & Publications (20)
High sensitivity of ovarian cancer cells to the synthetic triterpenoid CDDO-Imidazolide.
PMID 19364626·Cancer Lett·2009
8-other
Targeting Nrf2 with the triterpenoid CDDO-imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice.
PMID 19104057·Proc Natl Acad Sci U S A·2009
7-preclinical
Genetic versus chemoprotective activation of Nrf2 signaling: overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid-treated mice.
PMID 19386581·Carcinogenesis·2009
7-preclinical
Nrf2 is a critical modulator of the innate immune response in a model of uveitis.
PMID 19410644·Free Radic Biol Med·2009
7-preclinical
Anti-angiogenic activity of a novel class of chemopreventive compounds: oleanic acid terpenoids.
PMID 19213570·Recent Results Cancer Res·2009
6-review
Triterpenoid CDDO-methylamide improves memory and decreases amyloid plaques in a transgenic mouse model of Alzheimer's disease.
PMID 19200343·J Neurochem·2009
4-observational
Transcriptional regulation of the AP-1 and Nrf2 target gene sulfiredoxin.
PMID 19326073·Mol Cells·2009
6-review
Synthetic triterpenoids attenuate cytotoxic retinal injury: cross-talk between Nrf2 and PI3K/AKT signaling through inhibition of the lipid phosphatase PTEN.
PMID 19494206·Invest Ophthalmol Vis Sci·2009
7-preclinical
The triterpenoid CDDO-imidazolide confers potent protection against hyperoxic acute lung injury in mice.
PMID 19679692·Am J Respir Crit Care Med·2009
7-preclinical
Neuroprotective effects of the triterpenoid, CDDO methyl amide, a potent inducer of Nrf2-mediated transcription.
PMID 19484125·PLoS One·2009
7-preclinical
A novel acetylenic tricyclic bis-(cyano enone) potently induces phase 2 cytoprotective pathways and blocks liver carcinogenesis induced by aflatoxin.
PMID 18701497·Cancer Res·2008
7-preclinical
Glycogen synthase kinase 3beta regulates cell death induced by synthetic triterpenoids.
PMID 18757413·Cancer Res·2008
8-other
Concomitant DFMO and sulindac chemoprevention of colorectal adenomas: a major clinical advance.
PMID 18725921·Nat Clin Pract Oncol·2008
8-other
The synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid-imidazolide alters transforming growth factor beta-dependent signaling and cell migration by affecting the cytoskeleton and the polarity complex.
PMID 18283107·J Biol Chem·2008
7-preclinical
Human neuroblastoma cells rapidly enter cell cycle arrest and apoptosis following exposure to C-28 derivatives of the synthetic triterpenoid CDDO.
PMID 18277094·Cancer Biol Ther·2008
8-other
Activation of nuclear factor E2-related factor 2 in hereditary tyrosinemia type 1 and its role in survival and tumor development.
PMID 18666252·Hepatology·2008
7-preclinical
The synthetic triterpenoid CDDO-methyl ester modulates microglial activities, inhibits TNF production, and provides dopaminergic neuroprotection.
PMID 18474101·J Neuroinflammation·2008
7-preclinical
A dicyanotriterpenoid induces cytoprotective enzymes and reduces multiplicity of skin tumors in UV-irradiated mice.
PMID 18206646·Biochem Biophys Res Commun·2008
7-preclinical
Genetic or pharmacologic amplification of nrf2 signaling inhibits acute inflammatory liver injury in mice.
PMID 18417483·Toxicol Sci·2008
7-preclinical
The rexinoid LG100268 and the synthetic triterpenoid CDDO-methyl amide are more potent than erlotinib for prevention of mouse lung carcinogenesis.
PMID 18483313·Mol Cancer Ther·2008
7-preclinical
Data courtesy of the U.S. National Library of Medicine (NLM). Ltrl is not affiliated with or endorsed by NLM.
Contact & Hours
- Address
- 1499 CHAIN BRIDGE RD, SUITE 201
MC LEAN, VA 22101 - Phone
- (703) 288-9677
Quick Facts
- NPI
- 1154467959
- Entity Type
- Individual
- Gender
- Female
- Medicare
- Not confirmed
- Specialties
- 1
- Locations
- 1
- Publications
- 20
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