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KARL HOSTETLER, M.D.
M.D.
Internal Medicine Physician
NPI: 1477501450Individual
Specialties, Licenses & Credentials
Internal Medicine PhysicianPrimary
Internal Medicine
Code: 207R00000X
C32005(CA)
Endocrinology, Diabetes & Metabolism Physician
Internal Medicine — Endocrinology, Diabetes & Metabolism
Code: 207RE0101X
C32005(CA)
Research & Publications (20)
Alkoxyalkyl prodrugs of acyclic nucleoside phosphonates enhance oral antiviral activity and reduce toxicity: current state of the art.
PMID 19425198·Antiviral Res·2009
3-trial
Oral 1-O-octadecyl-2-O-benzyl-sn-glycero-3-cidofovir targets the lung and is effective against a lethal respiratory challenge with ectromelia virus in mice.
PMID 17123638·Antiviral Res·2007
7-preclinical
Alkoxyalkyl esters of (S)-9-[3-hydroxy-2-(phosphonomethoxy)propyl]adenine are potent inhibitors of the replication of wild-type and drug-resistant human immunodeficiency virus type 1 in vitro.
PMID 16870786·Antimicrob Agents Chemother·2006
4-observational
Enhanced antiproliferative effects of alkoxyalkyl esters of cidofovir in human cervical cancer cells in vitro.
PMID 16432174·Mol Cancer Ther·2006
8-other
In vitro and in vivo activity of 1-O-hexadecylpropanediol-3-phospho-ganciclovir and 1-O-hexadecylpropanediol-3-phospho-penciclovir in cytomegalovirus and herpes simplex virus infections.
PMID 11437323·Antivir Chem Chemother·2001
4-observational
Antiviral activities of oral 1-O-hexadecylpropanediol-3-phosphoacyclovir and acyclovir in woodchucks with chronic woodchuck hepatitis virus infection.
PMID 10858362·Antimicrob Agents Chemother·2000
7-preclinical
In vitro anti-HIV-1 activity of sn-2-substituted 1-O-octadecyl-sn-glycero-3-phosphonoformate analogues and synergy with zidovudine.
PMID 10901292·Antivir Chem Chemother·2000
8-other
The octadecyloxyethyl ester of (S)-9-[3-hydroxy-2-(phosphonomethoxy) propyl]adenine is a potent and selective inhibitor of hepatitis C virus replication in genotype 1A, 1B, and 2A replicons.
PMID 19289518·Antimicrob Agents Chemother·2009
8-other
Alkoxyalkyl esters of 9-(s)-(3-hydroxy-2-phosphonomethoxypropyl) adenine are potent and selective inhibitors of hepatitis B virus (HBV) replication in vitro and in HBV transgenic mice in vivo.
PMID 19398648·Antimicrob Agents Chemother·2009
7-preclinical
Comparative study of the photochemistry of the azidopyridine 1-oxides.
PMID 18399657·J Org Chem·2008
4-observational
Inhibition of herpesvirus replication by hexadecyloxypropyl esters of purine- and pyrimidine-based phosphonomethoxyethyl nucleoside phosphonates.
PMID 18852272·Antimicrob Agents Chemother·2008
8-other
Cidofovir and (S)-9-[3-hydroxy-(2-phosphonomethoxy)propyl]adenine are highly effective inhibitors of vaccinia virus DNA polymerase when incorporated into the template strand.
PMID 18056278·Antimicrob Agents Chemother·2008
8-other
Effect of oral treatment with (S)-HPMPA, HDP-(S)-HPMPA or ODE-(S)-HPMPA on replication of murine cytomegalovirus (MCMV) or human cytomegalovirus (HCMV) in animal models.
PMID 18336926·Antiviral Res·2008
7-preclinical
Effect of oral treatment with hexadecyloxypropyl-[(S)-9-(3-hydroxy-2- phosphonylmethoxypropyl)adenine] [(S)-HPMPA] or octadecyloxyethyl-(S)-HPMPA on cowpox or vaccinia virus infections in mice.
PMID 17846137·Antimicrob Agents Chemother·2007
7-preclinical
Intraocular properties of an alkoxyalkyl derivative of cyclic 9-(S)-(3-hydroxyl-2-phosphonomehoxypropyl) adenine, an intravitreally injectable anti-HCMV drug in rabbit and guinea pig.
PMID 17900229·J Ocul Pharmacol Ther·2007
7-preclinical
Synthesis and antiviral evaluation of alkoxyalkyl-phosphate conjugates of cidofovir and adefovir.
PMID 17367874·Antiviral Res·2007
4-observational
Antiviral activities of novel 5-phosphono-pent-2-en-1-yl nucleosides and their alkoxyalkyl phosphonoesters.
PMID 17130297·Antimicrob Agents Chemother·2007
8-other
Synthesis of the 5-phosphono-pent-2-en-1-yl nucleosides: a new class of antiviral acyclic nucleoside phosphonates.
PMID 17166725·Bioorg Med Chem·2007
8-other
In vitro evaluation of the anti-orf virus activity of alkoxyalkyl esters of CDV, cCDV and (S)-HPMPA.
PMID 17184854·Antiviral Res·2007
4-observational
Data courtesy of the U.S. National Library of Medicine (NLM). Ltrl is not affiliated with or endorsed by NLM.
Contact & Hours
- Address
- 200 W ARBOR DR, MAIL CODE 0726
SAN DIEGO, CA 92103 - Phone
- (858) 657-8440
Quick Facts
- NPI
- 1477501450
- Entity Type
- Individual
- Gender
- Male
- Medicare
- Not confirmed
- Specialties
- 2
- Locations
- 1
- Publications
- 20
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