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BERNADETTE CLEMENT, MD
Pediatrics Physician
NPI: 1699720805Individual
Specialties, Licenses & Credentials
Pediatrics PhysicianPrimary
Pediatrics
Code: 208000000X
206176(NY)
Research & Publications (20)
Diacetyldiamidoximeester of pentamidine, a prodrug for treatment of protozoal diseases: synthesis, in vitro and in vivo biotransformation.
PMID 17001612·ChemMedChem·2006
7-preclinical
Reduction of Nomega-hydroxy-L-arginine to L-arginine by pig liver microsomes, mitochondria, and human liver microsomes.
PMID 16959215·Biochem Biophys Res Commun·2006
7-preclinical
Hepatic, extrahepatic, microsomal, and mitochondrial activation of the N-hydroxylated prodrugs benzamidoxime, guanoxabenz, and Ro 48-3656 ([[1-[(2s)-2-[[4-[(hydroxyamino)iminomethyl]benzoyl]amino]-1-oxopropyl]-4-piperidinyl]oxy]-acetic acid).
PMID 16118330·Drug Metab Dispos·2005
4-observational
A two-step synthesis of cytostatically active benzo[c]phenanthridine derivatives.
PMID 15593276·Angew Chem Int Ed Engl·2005
8-other
Reduction of sulfamethoxazole and dapsone hydroxylamines by a microsomal enzyme system purified from pig liver and pig and human liver microsomes.
PMID 15862605·Life Sci·2005
7-preclinical
Characterization of in vitro biotransformation of new, orally active, direct thrombin inhibitor ximelagatran, an amidoxime and ester prodrug.
PMID 12695354·Drug Metab Dispos·2003
7-preclinical
Reduction of N-hydroxylated compounds: amidoximes (N-hydroxyamidines) as pro-drugs of amidines.
PMID 12214667·Drug Metab Rev·2002
6-review
Phase 2 metabolites of N-hydroxylated amidines (amidoximes): synthesis, in vitro formation by pig hepatocytes, and mutagenicity testing.
PMID 11258982·Chem Res Toxicol·2001
7-preclinical
Reduction of amphetamine hydroxylamine and other aliphatic hydroxylamines by benzamidoxime reductase and human liver microsomes.
PMID 11080052·Chem Res Toxicol·2000
7-preclinical
Incorporation of neutral C-terminal residues in 3-amidinophenylalanine-derived matriptase inhibitors.
PMID 19250826·Bioorg Med Chem Lett·2009
7-preclinical
Detection of metabolites of fumaric acid esters in human urine: implications for their mode of action.
PMID 18704112·J Invest Dermatol·2009
7-preclinical
A refined characterisation of the NeoHepatocyte phenotype necessitates a reappraisal of the transdifferentiation hypothesis.
PMID 19272525·Differentiation·2009
7-preclinical
Synthesis and evaluation of pyrido[1,2-a]pyrimidines as inhibitors of nitric oxide synthases.
PMID 19144449·Eur J Med Chem·2009
7-preclinical
Inhibitory effects on cytochrome p450 enzymes of pentamidine and its amidoxime pro-drug.
PMID 18346045·Basic Clin Pharmacol Toxicol·2008
8-other
Initial phase 2 trial of a nicotinic agonist in schizophrenia.
PMID 18381905·Am J Psychiatry·2008
3-trial
Genomic insights into Mn(II) oxidation by the marine alphaproteobacterium Aurantimonas sp. strain SI85-9A1.
PMID 18344346·Appl Environ Microbiol·2008
8-other
Involvement of stearoyl-CoA desaturase in the reduction of amidoxime prodrugs.
PMID 18609446·Xenobiotica·2008
7-preclinical
Structure-activity relationship of novel and known inhibitors of human dimethylarginine dimethylaminohydrolase-1: alkenyl-amidines as new leads.
PMID 19013076·Bioorg Med Chem·2008
8-other
N(delta)-Methylated L-arginine derivatives and their effects on the nitric oxide generating system.
PMID 18083522·Bioorg Med Chem·2008
7-preclinical
Prokineticin 2/Bv8 is expressed in Kupffer cells in liver and is down regulated in human hepatocellular carcinoma.
PMID 18300343·World J Gastroenterol·2008
8-other
Data courtesy of the U.S. National Library of Medicine (NLM). Ltrl is not affiliated with or endorsed by NLM.
Contact & Hours
- Address
- 650 FULTON ST
BROOKLYN, NY 11217 - Phone
- (718) 596-9800
Quick Facts
- NPI
- 1699720805
- Entity Type
- Individual
- Gender
- Female
- Medicare
- Not confirmed
- Specialties
- 1
- Locations
- 1
- Publications
- 20
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