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PAUL ROLLER, MD
MD
Geriatric Medicine (Internal Medicine) Physician
NPI: 1992811483Individual
Specialties, Licenses & Credentials
Geriatric Medicine (Internal Medicine) PhysicianPrimary
Internal Medicine — Geriatric Medicine
Code: 207RG0300X
18110(AL)
Research & Publications (20)
Discovery of thioether-bridged cyclic pentapeptides binding to Grb2-SH2 domain with high affinity.
PMID 19362470·Bioorg Med Chem Lett·2009
8-other
Design and characterization of bivalent Smac-based peptides as antagonists of XIAP and development and validation of a fluorescence polarization assay for XIAP containing both BIR2 and BIR3 domains.
PMID 18023397·Anal Biochem·2008
4-observational
Interaction of a cyclic, bivalent smac mimetic with the x-linked inhibitor of apoptosis protein.
PMID 18717598·Biochemistry·2008
8-other
Pyrogallol-based molecules as potent inhibitors of the antiapoptotic Bcl-2 proteins.
PMID 17378545·J Med Chem·2007
8-other
Design and synthesis of a new, conformationally constrained, macrocyclic small-molecule inhibitor of STAT3 via 'click chemistry'.
PMID 17513110·Bioorg Med Chem Lett·2007
8-other
Structure-based design of flavonoid compounds as a new class of small-molecule inhibitors of the anti-apoptotic Bcl-2 proteins.
PMID 17552510·J Med Chem·2007
8-other
Design, synthesis, and characterization of a potent, nonpeptide, cell-permeable, bivalent Smac mimetic that concurrently targets both the BIR2 and BIR3 domains in XIAP.
PMID 17999504·J Am Chem Soc·2007
8-other
Design and synthesis of redox stable analogues of sunflower trypsin inhibitors (SFTI-1) on solid support, potent inhibitors of matriptase.
PMID 17192072·Org Lett·2007
8-other
Design and synthesis of novel and potent inhibitors of the type II transmembrane serine protease, matriptase, based upon the sunflower trypsin inhibitor-1.
PMID 17985858·J Med Chem·2007
8-other
Design and synthesis of paclitaxel conjugated with an ErbB2-recognizing peptide, EC-1.
PMID 17879382·Biopolymers·2007
8-other
Structure-based design of potent Grb2-SH2 domain antagonists not relying on phosphotyrosine mimics.
PMID 16945340·Biochem Biophys Res Commun·2006
7-preclinical
Design and concise synthesis of fully protected analogues of l-gamma-carboxyglutamic acid.
PMID 16958524·J Org Chem·2006
8-other
Structure-based design of potent small-molecule inhibitors of anti-apoptotic Bcl-2 proteins.
PMID 17034116·J Med Chem·2006
8-other
Structure-based design of spiro-oxindoles as potent, specific small-molecule inhibitors of the MDM2-p53 interaction.
PMID 16759082·J Med Chem·2006
8-other
Discovery of a novel nonphosphorylated pentapeptide motif displaying high affinity for Grb2-SH2 domain by the utilization of 3'-substituted tyrosine derivatives.
PMID 16509576·J Med Chem·2006
8-other
Covalent binding of the natural antimicrobial peptide indolicidin to DNA abasic sites.
PMID 16998183·Nucleic Acids Res·2006
8-other
New HIV-1 reverse transcriptase inhibitors based on a tricyclic benzothiophene scaffold: synthesis, resolution, and inhibitory activity.
PMID 16527484·Bioorg Med Chem Lett·2006
8-other
Binding affinity difference induced by the stereochemistry of the sulfoxide bridge of the cyclic peptide inhibitors of Grb2-SH2 domain: NMR studies for the structural origin.
PMID 15823578·Biochem Biophys Res Commun·2005
8-other
Structure-based design, synthesis and biochemical testing of novel and potent Smac peptido-mimetics.
PMID 15664859·Bioorg Med Chem Lett·2005
8-other
Data courtesy of the U.S. National Library of Medicine (NLM). Ltrl is not affiliated with or endorsed by NLM.
Contact & Hours
- Address
- 1 LAKESHORE DRIVE, STE 200
BIRMINGHAM, AL 35209 - Phone
- (205) 916-0105
Quick Facts
- NPI
- 1992811483
- Entity Type
- Individual
- Gender
- Male
- Medicare
- Not confirmed
- Specialties
- 1
- Locations
- 1
- Publications
- 20
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